CASE REPORT Reproductive endocrinology
نویسنده
چکیده
Failure to retrieve oocytes after normal ovarian stimulation has been labeled ‘empty follicle syndrome’ (EFS). The existence of genuine EFS has been questioned and is still controversial. Here, we report an unusual case in which an extraordinary number of empty follicle-like structures were identified in the ovarian aspirate at the time of retrieval. A 31-year-old woman presented with a 4-year history of primary infertility and underwent ovulation induction. The patient was given hCG and oocyte retrieval was performed 36 h later. During the oocyte retrieval, more than 200 tiny structures resembling pre-antral follicles were noted in the ovarian aspirate. They exhibited two to three layers of granulosa cells and appeared to enclose an immature oocyte. They showed a great variation in size ranging between 40 and 80 mm. These structures were further characterized by electron microscopy and cultivated in vitro to assess hormone secretion. The follicles were found to be devoid of oocytes, but each had a readily identifiable zona. Hormone assays revealed that these follicles were secreting increasing levels of estradiol. A second in vitro fertilization attempt gave similar results. These data are suggestive of some failure in the oocyte maturation process. We speculate that this may be the first actual evidence to support the existence of true empty follicles, which if left to grow in vivo might lead to empty graffian follicles and genuine EFS.
منابع مشابه
Endometrial Adenocarcinoma in A 31-Year Old Woman: A Case Report
Endometrial adenocarcinoma (EC) usually occurs after menopause, whereas in 2-14% of cases, it occurs in young patients (less than 40 years old) who may desire to keep their fertility. It is of importance to evaluate women for EC when they develop polycystic ovarian syndrome and abnormal uterine bleeding. Its treatment includes hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenec...
متن کاملOnm-2: Evaluation of The Quality of Life in Iranian Women with Infertility: A Case-Control Study
Background The aim of this study was to evaluate the hypothesis that infertility may result in a decrease in quality of life (QOL). MaterialsAndMethods In this case control study that carried out on 150 women with infertility and 150 women undergone TL as the control group. The participants were asked to fill out the Short Form Health Survey (SF-12) questionnaire, a generic instrument to measur...
متن کاملDiagnostic Accuracy of Body Mass Index and Fasting Glucose for The Prediction of Gestational Diabetes Mellitus after Assisted Reproductive Technology
Objective Background: To determine maternal pre-pregnancy body mass index (BMI), first trimester fasting blood sugar (FBS) and the combination (BMI+FBS) cut-points for at risk pregnant women conceived by assisted reproduction technology (ART) to better prediction of infertile women’s risk of developing gestational diabetes mellitus (GDM). MaterialsAndMethods In this nested case-control study, 2...
متن کاملStruma Ovarii With the Coexistence of Hashimoto’s Thyroiditis: A Case Report
Background: Struma ovarii (SO) is a rare phenomenon. In addition, it can be identified from the histological assessment and may show the characteristics of Hashimoto’s thyroiditis in rare cases. In several cases, malignant stroma ovarii is found to produce hyperthyroidism while very few cases are reported with Hashimoto’s thyroiditis. The present study reported SO co-incident with Hashimoto’s t...
متن کاملLingual Thyroid: A Case Report and Literature Review
Thyroid ectopia is a dysgenesis of thyroid gland and Lingual position represents the most frequent ectopic location accounting up to 90% of ectopic cases. Hypothyroidism is commonly present because of absence of a normal thyroid gland in most instances. Primary hypothyroidism in juvenile population generally leads to retardation of linear growth and delay or even arrested puberty. We present a ...
متن کامل